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The functional costs and benefits of dietary restriction in Drosophila

Burger, Joep M. S. ; Hwangbo, Dae Sung ; Corby-Harris, Vanessa ; Promislow, Daniel E. L.

In: Aging Cell, 2007, vol. 6, no. 1, p. 63–71.

Dietary restriction (DR) extends lifespan in an impressively wide array of species spanning three eukaryotic kingdoms. In sharp contrast, relatively little is known about the effects of DR on functional senescence, with most of the work having been done on mice and rats. Here we used Drosophila melanogaster to test the assumption that lifespan extension through DR slows down age-related...